the accurate prediction of human pharmacokinetics (PK) of candidate monoclonal antibodies non-clinical data is essential to maximize the success of clinical trials. However, to monoclonal antibodies exhibiting nonlinear license for target-mediated disposition, PK prediction is specifically challenging. challenge is further compounded because the molecule is less cross-reactivity in nonhuman primates, in terms of surrogate antibody selectively targets in rodents may be required.
For this case, the prediction of human PK must take into account any interspecies differences in the kinetics of binding, expression of the target, the target turnover, and the potential epitopes. We present here a method based models to predict human PK MAB92 (also known as BI 655 130), a humanized IgG1 <MML: math> κ </ MML: math> monoclonal antibody directed against human IL-36R. PK preclinical results in a chimeric mouse with rat anti-mouse IgG2a surrogate antibody cross-reactive to mouse IL-36R.
Parameters specific targets such as antibody binding affinity (K <sub> D </ sub>), the rate of internalization of targets complex (k <sub> int </ sub>), the rate of degradation of the target (k <sub> deg </ sub >), and goals galore (R <sub> 0 </ sub>) is integrated into the model. Two different methods for placing human R <sub> 0 </ sub> were evaluated: the first assumed comparable expression between humans and mice and the second used a high resolution mRNA transcriptome data (FANTOM5) as a replacement for expression.
Utilizing mouse R <sub> 0 </ sub> to predict human PK, AUC <sub> 0-∞ </ sub> substantially underpredicted to nonsaturating dose; However, after correcting the RNA transcriptome differences between species, AUC <sub> 0-∞ </ sub> is expected to largely within 1.5 times of the observations in the first study-in-human, showing the validity of the modeling approach. Our results show that the semi-mechanistic model of RNA transcriptome and entering data specific target parameters may improve predictivity of PK’s first-in-human.
Ectodysplasin role of signals in the middle ear and nasal pathology in the rat and mouse models of hypohidrotic ectodermal dysplasia.
Patients with mutations in the gene ectodysplasin receptor signaling pathway – X-linked ligands ectodysplasin-A (EDA), receptor or adapter EDAR receptor EDARADD – have hypohidrotic ectodermal dysplasia (HED). In addition to having the development of dental disorders, hair, eccrine sweat glands and salivary glands and milk, HED patients had ear, nose and throat diseases. Mouse strains Tabby (edata) and downless (Edardl-J / dl-J) had rhinitis and otitis media due to the loss of submucosal glands in the upper airway.
We reported that prenatal correction of the signal in the EDAR edata rescue mice with anti-EDAR agonist antibody auditory tube submucosal glands and prevent otitis media, rhinitis and nasopharyngitis. The sparse- and wavy hair (SWH) strains of mice carrying mutations in the gene and has a phenotype HED Edaradd skin similar to a mouse model. We reported that the auditory tube of submucosal gland is smaller in homozygous mutant Edaraddswh / SWH than in unaffected heterozygous Edaraddswh / + mice, and that this predisposes them otitis media.
Furthermore, the pathogenesis of otitis media in a rat model HED different from that in mice, such as otitis media is the primary pathology, and rhinitis is a later-onset phenotype. These findings in mice suggest that the model HED hypomorphic and null mutation in the EDAR gene signal pathway may predispose to otitis media in humans. In addition, this work showed that prenatal most recent successful of X-linked HED (XLHED) in humans can also prevent ear, nose and throat diseases, and provide diagnostic criteria that distinguish HED-associated otitis media from chronic otitis media with effusion, which common in children.
homology models of mouse and rat estrogen receptor-α ligand binding domain are made by in silico mutagenesis of human template: molecular docking with 17ß-estradiol, diethylstilbestrol, and analog paraben.
crystal structures exist for humans, but not rodents, estrogen receptor-α ligand binding domain (ERα-LBD). As a result, studies of rodents which involves binding to ERα-LBD compounds are limited in their molecular-level interpretation and extrapolation to humans. Because mouse and human sequences ERα-LBDs is> 95% identical, we expected a 3D structure and ligand binding them to be very similar.
To test this hypothesis, we used human ERα-LBD structure (PDB 3UUD) as a template to generate mouse and rat models of homology. Employing a mouse model and human structure, we generated docking pose of 23 Group A ligand (17ß-estradiol, diethylstilbestrol, and 21 analog parabens) in Autodock Vina for interspecies comparison. Ligands RMSDs (Å) (median, 95% CI) was 0.49 (0.21 to 1.82) (human-mouse) and 1.19 (0.22 to 1.82) (human-mouse), far below the range of 2.0-2.5 Å for docking pose similar. Number of interspecies ligand-receptor contact residues are very similar, with Sorensen Sc (%) = 96.8 (90,0-100) (human-mouse) and 97.7 (89.5 to 100) (human-mouse).
Likewise, the amount of ligand-receptor interspecies contact residues were highly correlated: Pearson r = 0.913 (human-mouse) and 0925 (human-mouse). The amount of ligand-receptor interspecies contact is even more closely correlated atom: r = 0.979 (human-mouse) and 0.986 (human-mouse). Pyramid plot atomic number ligand-receptor contact residue between species exhibited high symmetry and has Spearman rs = 0.977 (human-mouse) and 0.966 (human-mouse). Group B included 15 paraben ligand substituted ring was recently shown experimentally to exhibit decreased binding of human ERα and to exert the antimicrobial activity enhancement. Ligand docking efficiency is calculated from the ligand to human ERα-LBD are well correlated with those derived from published experimental data (Pearson partial rp = 0.894 and 0.918; group A and B, respectively).
Coenzyme Q10 |
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| GP6626 | Glentham Life Sciences | 100mg | EUR 103.51 |
Coenzyme Q10 |
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| HY-N0111 | MedChemExpress | 5g | EUR 362.4 |
Coenzyme Q10 |
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| N1796-200 | ApexBio | 200 mg | EUR 32 |
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Description: Extracted from Coenzyme Q10;Suitability:Chloroform,benzene and carbon tetrachloride;Store the product in sealed,cool and dry condition |
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Coenzyme Q10 |
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| N1796-5.1 | ApexBio | 10 mM (in 1mL DMSO) | EUR 129.6 |
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Description: Extracted from Coenzyme Q10;Suitability:Chloroform,benzene and carbon tetrachloride;Store the product in sealed,cool and dry condition |
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Coenzyme Q10 |
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| GP6626-1 | Glentham Life Sciences | 1 | EUR 52.8 |
Coenzyme Q10 |
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| GP6626-100 | Glentham Life Sciences | 100 | EUR 19.8 |
Coenzyme Q10 |
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| GP6626-100MG | Glentham Life Sciences | 100 mg | EUR 60 |
Coenzyme Q10 |
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| GP6626-1G | Glentham Life Sciences | 1 g | EUR 112.8 |
Coenzyme Q10 |
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| GP6626-5 | Glentham Life Sciences | 5 | EUR 113.1 |
Coenzyme Q10 |
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| T2796-10mg | TargetMol Chemicals | 10mg | Ask for price |
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Description: Coenzyme Q10 |
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Coenzyme Q10 |
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| T2796-1g | TargetMol Chemicals | 1g | Ask for price |
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Description: Coenzyme Q10 |
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Coenzyme Q10 |
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| T2796-1mg | TargetMol Chemicals | 1mg | Ask for price |
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Description: Coenzyme Q10 |
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Coenzyme Q10 |
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| T2796-50mg | TargetMol Chemicals | 50mg | Ask for price |
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Description: Coenzyme Q10 |
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Coenzyme Q10 |
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| T2796-5mg | TargetMol Chemicals | 5mg | Ask for price |
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Description: Coenzyme Q10 |
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Coenzyme Q10 |
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| TB0064 | ChemNorm | 10X20mg | EUR 328.8 |
Coenzyme Q10 |
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| MBS3603958-200mg | MyBiosource | 200mg | EUR 200 |
Coenzyme Q10 |
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| MBS3603958-5x200mg | MyBiosource | 5x200mg | EUR 580 |
Coenzyme Q10 (Vitamin-Q10, Ubichinon-50, Ubidecarenone, Coenzyme-Q10, Ubiquinone-Q10) |
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| MBS6110758-10g | MyBiosource | 10g | EUR 640 |
Coenzyme Q10 (Vitamin-Q10, Ubichinon-50, Ubidecarenone, Coenzyme-Q10, Ubiquinone-Q10) |
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| MBS6110758-1g | MyBiosource | 1(g | EUR 345 |
Coenzyme Q10 (Vitamin-Q10, Ubichinon-50, Ubidecarenone, Coenzyme-Q10, Ubiquinone-Q10) |
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| MBS6110758-25g | MyBiosource | 25g | EUR 860 |
Coenzyme Q10 (Vitamin-Q10, Ubichinon-50, Ubidecarenone, Coenzyme-Q10, Ubiquinone-Q10) |
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| MBS6110758-50g | MyBiosource | 50g | EUR 1105 |
Coenzyme Q10 (Vitamin-Q10, Ubichinon-50, Ubidecarenone, Coenzyme-Q10, Ubiquinone-Q10) |
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| MBS6110758-5g | MyBiosource | 5g | EUR 500 |
(2Z)-Coenzyme Q10 |
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| C636565 | Toronto Research Chemicals | 25mg | EUR 12800 |
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Description: 65085-29-2 |
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Coenzyme Q10-d6 |
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| C636502 | Toronto Research Chemicals | 25mg | EUR 10500 |
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Description: 1331655-96-9 |
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Coenzyme Q10 (CoQ10) |
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| MBS577727-100mg | MyBiosource | 100mg | EUR 145 |
Coenzyme Q10 (CoQ10) |
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| MBS577727-200mg | MyBiosource | 200mg | EUR 150 |
Coenzyme Q10 (CoQ10) |
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| MBS577727-25mg | MyBiosource | 25mg | EUR 120 |
Coenzyme Q10 (CoQ10) |
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| MBS577727-500mg | MyBiosource | 500mg | EUR 185 |
Coenzyme Q10 (CoQ10) |
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| MBS577727-50mg | MyBiosource | 50mg | EUR 135 |
Coenzyme Q10 (CoQ10) |
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| MBS386330-1g | MyBiosource | 1g | EUR 230 |
Coenzyme Q10 (CoQ10) |
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| MBS386330-200mg | MyBiosource | 200mg | EUR 135 |
Coenzyme Q10 (CoQ10) |
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| MBS386330-500mg | MyBiosource | 500mg | EUR 170 |
Coenzyme Q10 (CoQ10) |
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| MBS386330-5x1g | MyBiosource | 5x1g | EUR 1030 |
Coenzyme Q10 extrapure, 99% |
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| 15039 | Sisco Laboratories | 100 Mg | EUR 5.48 |
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Description: Part B |
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Active Coenzyme Q10 Liposome |
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| CLP-020 | Creative BioMart | 1kg | EUR 399.2 |
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Description: Greater than 95% |
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Active Coenzyme Q10 Liposome |
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| Lipo-144C | Creative BioMart | Each | EUR 325.38 |
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Description: Liposome |
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Coenzyme Q10, Hi-LR™ |
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| RM6818-100MG | EWC Diagnostics | 1 unit | EUR 15.67 |
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Description: Coenzyme Q10, Hi-LR™ |
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Coenzyme Q10, Hi-LR™ |
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| RM6818-1G | EWC Diagnostics | 1 unit | EUR 125.75 |
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Description: Coenzyme Q10, Hi-LR™ |
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Coenzyme Q10, Hi-LR™ |
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| RM6818-500MG | EWC Diagnostics | 1 unit | EUR 69.9 |
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Description: Coenzyme Q10, Hi-LR™ |
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Rat Coenzyme Q10 ELISA Kit |
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| SL1123Ra | Sunlong | - | EUR 498 |
Coenzyme Q10 (COQ10) ELISA Kit |
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| abx159767-96tests | Abbexa | 96 tests | EUR 1356 |
Coenzyme Q10 (COQ10) ELISA Kit |
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| abx159767-100g | Abbexa | 100 µg | Ask for price |
Coenzyme Q10 (COQ10) ELISA Kit |
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| abx159767-10g | Abbexa | 10 µg | EUR 743.75 |
Coenzyme Q10 (COQ10) ELISA Kit |
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| abx159767-50g | Abbexa | 50 µg | Ask for price |
Human Coenzyme Q10 ELISA Kit |
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| MBS3801946-10x96StripWells | MyBiosource | 10x96-Strip-Wells | EUR 6725 |
Human Coenzyme Q10 ELISA Kit |
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| MBS3801946-48StripWells | MyBiosource | 48-Strip-Wells | EUR 550 |
Human Coenzyme Q10 ELISA Kit |
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| MBS3801946-5x96StripWells | MyBiosource | 5x96-Strip-Wells | EUR 3420 |
Human Coenzyme Q10 ELISA Kit |
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| MBS3801946-96StripWells | MyBiosource | 96-Strip-Wells | EUR 765 |
Coenzyme Q10 Microplate Assay Kit |
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| DLSM0229 | DL Develop | 100 Assays | EUR 245 |
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Description: Detection and Quantification of Coenzyme Q10 Content. |
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Coenzyme Q10 Microplate Assay Kit |
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| MBS8309728-100Assays | MyBiosource | 100Assays | EUR 365 |
Coenzyme Q10 Microplate Assay Kit |
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| MBS8309728-5x100Assays | MyBiosource | 5x100Assays | EUR 1580 |
Coenzyme Q10 Microplate Assay Kit |
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| RDSM229 | Reddot Biotech | 100 Assays | EUR 245 |
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Description: Detection and Quantification of Coenzyme Q10 Content. |
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Rat Coenzyme Q10 (CoQ10) ELISA kit |
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| E02C1947-192T | BlueGene | 192 tests | EUR 1524 |
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Description: A competitive ELISA for quantitative measurement of Rat Coenzyme Q10 (CoQ10) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Rat Coenzyme Q10 (CoQ10) ELISA kit |
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| E02C1947-48 | BlueGene | 1 plate of 48 wells | EUR 624 |
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Description: A competitive ELISA for quantitative measurement of Rat Coenzyme Q10 (CoQ10) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Rat Coenzyme Q10 (CoQ10) ELISA kit |
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| E02C1947-96 | BlueGene | 1 plate of 96 wells | EUR 822 |
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Description: A competitive ELISA for quantitative measurement of Rat Coenzyme Q10 (CoQ10) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Pig Coenzyme Q10 (CoQ10) ELISA kit |
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| E07C1947-192T | BlueGene | 192 tests | EUR 1524 |
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Description: A competitive ELISA for quantitative measurement of Porcine Coenzyme Q10 (CoQ10) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Pig Coenzyme Q10 (CoQ10) ELISA kit |
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| E07C1947-48 | BlueGene | 1 plate of 48 wells | EUR 624 |
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Description: A competitive ELISA for quantitative measurement of Porcine Coenzyme Q10 (CoQ10) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Pig Coenzyme Q10 (CoQ10) ELISA kit |
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| E07C1947-96 | BlueGene | 1 plate of 96 wells | EUR 822 |
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Description: A competitive ELISA for quantitative measurement of Porcine Coenzyme Q10 (CoQ10) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Dog Coenzyme Q10 (CoQ10) ELISA kit |
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| E08C1947-192T | BlueGene | 192 tests | EUR 1524 |
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Description: A competitive ELISA for quantitative measurement of Canine Coenzyme Q10 (CoQ10) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Dog Coenzyme Q10 (CoQ10) ELISA kit |
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| E08C1947-48 | BlueGene | 1 plate of 48 wells | EUR 624 |
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Description: A competitive ELISA for quantitative measurement of Canine Coenzyme Q10 (CoQ10) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Dog Coenzyme Q10 (CoQ10) ELISA kit |
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| E08C1947-96 | BlueGene | 1 plate of 96 wells | EUR 822 |
|
Description: A competitive ELISA for quantitative measurement of Canine Coenzyme Q10 (CoQ10) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Rat Coenzyme Q10(CoQ10) Elisa Kit |
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| EK721187 | AFG Bioscience LLC | 96 Wells | EUR 0.63 |
Rat Coenzyme Q10 (CoQ10) ELISA kit |
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| E01A12187 | BlueGene | 96T | EUR 700 |
|
Description: ELISA |
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Rat Coenzyme Q10(COQ10)ELISA Kit |
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| YLA1469RA-48T | Shanghai YL Biotech | 48T | Ask for price |
Rat Coenzyme Q10(COQ10)ELISA Kit |
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| YLA1469RA-96T | Shanghai YL Biotech | 96T | Ask for price |
Rat Coenzyme Q10,CoQ10 ELISA KIT |
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| E2429Ra-1096T | Jiaxing Korain Biotech Ltd (BT Labs) | 10*96T | EUR 4122 |
Rat Coenzyme Q10,CoQ10 ELISA KIT |
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| E2429Ra-48wells | Jiaxing Korain Biotech Ltd (BT Labs) | 48 wells | EUR 300 |
Rat Coenzyme Q10,CoQ10 ELISA KIT |
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| E2429Ra-596T | Jiaxing Korain Biotech Ltd (BT Labs) | 5*96T | EUR 2061 |
Rat Coenzyme Q10,CoQ10 ELISA KIT |
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| E2429Ra-96wells | Jiaxing Korain Biotech Ltd (BT Labs) | 96 wells | EUR 458 |
Dog CoQ10(Coenzyme Q10) ELISA Kit |
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| ELK0884-48T | ELK Biotech | 48T | Ask for price |
|
Description: This assay employs the competitive inhibition enzyme immunoassay technique. The microtiter plate provided in this kit has been pre-coated with Dog CoQ10 protein. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Dog CoQ10. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Dog CoQ10 in the samples is then determined by comparing the OD of the samples to the standard curve. |
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Dog CoQ10(Coenzyme Q10) ELISA Kit |
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| ELK0884-96T | ELK Biotech | 96T | Ask for price |
|
Description: This assay employs the competitive inhibition enzyme immunoassay technique. The microtiter plate provided in this kit has been pre-coated with Dog CoQ10 protein. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Dog CoQ10. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Dog CoQ10 in the samples is then determined by comparing the OD of the samples to the standard curve. |
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Rat CoQ10(Coenzyme Q10) ELISA Kit |
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| ELK9442-48T | ELK Biotech | 48T | Ask for price |
|
Description: This assay employs the competitive inhibition enzyme immunoassay technique. The microtiter plate provided in this kit has been pre-coated with Rat CoQ10 protein. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Rat CoQ10. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Rat CoQ10 in the samples is then determined by comparing the OD of the samples to the standard curve. |
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Rat CoQ10(Coenzyme Q10) ELISA Kit |
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| ELK9442-96T | ELK Biotech | 96T | Ask for price |
|
Description: This assay employs the competitive inhibition enzyme immunoassay technique. The microtiter plate provided in this kit has been pre-coated with Rat CoQ10 protein. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Rat CoQ10. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Rat CoQ10 in the samples is then determined by comparing the OD of the samples to the standard curve. |
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Rat Coenzyme Q10 (CoQ10) ELISA Kit |
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| MBS7241152-10x96StripWells | MyBiosource | 10x96-Strip-Wells | EUR 5685 |
Rat Coenzyme Q10 (CoQ10) ELISA Kit |
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| MBS7241152-48StripWells | MyBiosource | 48-Strip-Wells | EUR 485 |
Rat Coenzyme Q10 (CoQ10) ELISA Kit |
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| MBS7241152-5x96StripWells | MyBiosource | 5x96-Strip-Wells | EUR 3020 |
Rat Coenzyme Q10 (CoQ10) ELISA Kit |
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| MBS7241152-96StripWells | MyBiosource | 96-Strip-Wells | EUR 690 |
Rat Coenzyme Q10 (COQ10) ELISA Kit |
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| MBS9364193-10x96StripWells | MyBiosource | 10x96-Strip-Wells | EUR 6725 |
Rat Coenzyme Q10 (COQ10) ELISA Kit |
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| MBS9364193-48StripWells | MyBiosource | 48-Strip-Wells | EUR 550 |
Rat Coenzyme Q10 (COQ10) ELISA Kit |
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| MBS9364193-5x96StripWells | MyBiosource | 5x96-Strip-Wells | EUR 3420 |
Rat Coenzyme Q10 (COQ10) ELISA Kit |
|||
| MBS9364193-96StripWells | MyBiosource | 96-Strip-Wells | EUR 765 |
Cat Coenzyme Q10 (COQ10) ELISA Kit |
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| MBS9368801-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Rat CoQ10 (Coenzyme Q10) ELISA Kit |
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| MBS8820054-10x96StripWells | MyBiosource | 10x96-Strip-Wells | EUR 3130 |
Rat CoQ10 (Coenzyme Q10) ELISA Kit |
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| MBS8820054-48StripWells | MyBiosource | 48-Strip-Wells | EUR 350 |
Rat CoQ10 (Coenzyme Q10) ELISA Kit |
|||
| MBS8820054-5x96StripWells | MyBiosource | 5x96-Strip-Wells | EUR 1710 |
Rat CoQ10 (Coenzyme Q10) ELISA Kit |
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| MBS8820054-96StripWells | MyBiosource | 96-Strip-Wells | EUR 445 |
Dog CoQ10 (Coenzyme Q10) ELISA Kit |
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| MBS8820258-10x96StripWells | MyBiosource | 10x96-Strip-Wells | EUR 3130 |
Dog CoQ10 (Coenzyme Q10) ELISA Kit |
|||
| MBS8820258-48StripWells | MyBiosource | 48-Strip-Wells | EUR 350 |
Dog CoQ10 (Coenzyme Q10) ELISA Kit |
|||
| MBS8820258-5x96StripWells | MyBiosource | 5x96-Strip-Wells | EUR 1710 |
Dog CoQ10 (Coenzyme Q10) ELISA Kit |
|||
| MBS8820258-96StripWells | MyBiosource | 96-Strip-Wells | EUR 445 |
Rat Coenzyme Q10, CoQ10 ELISA Kit |
|||
| MBS1604105-10x96StripWells | MyBiosource | 10x96-Strip-Wells | EUR 3955 |
Rat Coenzyme Q10, CoQ10 ELISA Kit |
|||
| MBS1604105-48StripWells | MyBiosource | 48-Strip-Wells | EUR 305 |
Rat Coenzyme Q10, CoQ10 ELISA Kit |
|||
| MBS1604105-5x96StripWells | MyBiosource | 5x96-Strip-Wells | EUR 2005 |
Rat Coenzyme Q10, CoQ10 ELISA Kit |
|||
| MBS1604105-96StripWells | MyBiosource | 96-Strip-Wells | EUR 475 |
Goat Coenzyme Q10 (CoQ10) ELISA kit |
|||
| E01A47099 | BlueGene | 96T | EUR 700 |
|
Description: ELISA |
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Goat Coenzyme Q10 (CoQ10) ELISA kit |
|||
| E06C1947-192T | BlueGene | 192 tests | EUR 1524 |
|
Description: A competitive ELISA for quantitative measurement of Goat Coenzyme Q10 (CoQ10) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Goat Coenzyme Q10 (CoQ10) ELISA kit |
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| E06C1947-48 | BlueGene | 1 plate of 48 wells | EUR 624 |
|
Description: A competitive ELISA for quantitative measurement of Goat Coenzyme Q10 (CoQ10) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
|||
Goat Coenzyme Q10 (CoQ10) ELISA kit |
|||
| E06C1947-96 | BlueGene | 1 plate of 96 wells | EUR 822 |
|
Description: A competitive ELISA for quantitative measurement of Goat Coenzyme Q10 (CoQ10) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
|||
Goat Coenzyme Q10 (CoQ10) ELISA Kit |
|||
| SL0043Gt | Sunlong | - | Ask for price |
Goat Coenzyme Q10 (CoQ10) ELISA Kit |
|||
| MBS7226934-10x96StripWells | MyBiosource | 10x96-Strip-Wells | EUR 5685 |
Goat Coenzyme Q10 (CoQ10) ELISA Kit |
|||
| MBS7226934-48StripWells | MyBiosource | 48-Strip-Wells | EUR 485 |
Goat Coenzyme Q10 (CoQ10) ELISA Kit |
|||
| MBS7226934-5x96StripWells | MyBiosource | 5x96-Strip-Wells | EUR 3020 |
Goat Coenzyme Q10 (CoQ10) ELISA Kit |
|||
| MBS7226934-96StripWells | MyBiosource | 96-Strip-Wells | EUR 690 |
Cavy Coenzyme Q10 (COQ10) ELISA Kit |
|||
| MBS9359063-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Goat Coenzyme Q10 (COQ10) ELISA Kit |
|||
| MBS9365975-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Fish Coenzyme Q10 (COQ10) ELISA Kit |
|||
| MBS9346484-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Duck Coenzyme Q10 (COQ10) ELISA Kit |
|||
| MBS9354802-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Mouse Coenzyme Q10 (CoQ10) ELISA kit |
|||
| E01A20928 | BlueGene | 96T | EUR 700 |
|
Description: ELISA |
|||
Human Coenzyme Q10 (CoQ10) ELISA kit |
|||
| E01A3426 | BlueGene | 96T | EUR 700 |
|
Description: ELISA |
|||
Mouse Coenzyme Q10 (CoQ10) ELISA kit |
|||
| E03C1947-192T | BlueGene | 192 tests | EUR 1524 |
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Description: A competitive ELISA for quantitative measurement of Mouse Coenzyme Q10 (CoQ10) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Mouse Coenzyme Q10 (CoQ10) ELISA kit |
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| E03C1947-48 | BlueGene | 1 plate of 48 wells | EUR 624 |
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Description: A competitive ELISA for quantitative measurement of Mouse Coenzyme Q10 (CoQ10) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Mouse Coenzyme Q10 (CoQ10) ELISA kit |
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| E03C1947-96 | BlueGene | 1 plate of 96 wells | EUR 822 |
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Description: A competitive ELISA for quantitative measurement of Mouse Coenzyme Q10 (CoQ10) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Human Coenzyme Q10 (CoQ10) ELISA kit |
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| E01C1947-192T | BlueGene | 192 tests | EUR 1524 |
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Description: A competitive ELISA for quantitative measurement of Human Coenzyme Q10 (CoQ10) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Human Coenzyme Q10 (CoQ10) ELISA kit |
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| E01C1947-48 | BlueGene | 1 plate of 48 wells | EUR 624 |
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Description: A competitive ELISA for quantitative measurement of Human Coenzyme Q10 (CoQ10) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Human Coenzyme Q10 (CoQ10) ELISA kit |
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| E01C1947-96 | BlueGene | 1 plate of 96 wells | EUR 822 |
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Description: A competitive ELISA for quantitative measurement of Human Coenzyme Q10 (CoQ10) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Sheep Coenzyme Q10 (CoQ10) ELISA kit |
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| E01A99393 | BlueGene | 96T | EUR 700 |
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Description: ELISA |
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Human Coenzyme Q10 (CoQ10) ELISA Kit |
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| EKC33185-48T | Biomatik Corporation | 48T | EUR 597.24 |
Human Coenzyme Q10 (CoQ10) ELISA Kit |
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| EKC33185-5x96T | Biomatik Corporation | 5x96T | EUR 4052.7 |
Human Coenzyme Q10 (CoQ10) ELISA Kit |
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| EKC33185-96T | Biomatik Corporation | 96T | EUR 853.2 |
Human Coenzyme Q10(CoQ10) Elisa Kit |
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| EK710831 | AFG Bioscience LLC | 96 Wells | EUR 0.12 |
Human Coenzyme Q10 (CoQ10) ELISA Kit |
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| EK11069 | SAB | 96Т | EUR 799 |
Human Coenzyme Q10 (CoQ10) ELISA Kit |
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| AE49401HU-48Tests | Abebio | 48 Tests | EUR 360 |
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Description: Human (Homo sapiens) |
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Human Coenzyme Q10 (CoQ10) ELISA Kit |
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| AE49401HU-96Tests | Abebio | 96 Tests | EUR 680 |
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Description: Human (Homo sapiens) |
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Human Coenzyme Q10 (CoQ10) ELISA Kit |
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| CSB-E14081h-24T | Cusabio | 1 plate of 24 wells | EUR 198 |
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Description: Quantitativecompetitive ELISA kit for measuring Human Coenzyme Q10 (CoQ10) in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price. |
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Human Coenzyme Q10 (CoQ10) ELISA Kit |
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| 1-CSB-E14081h | Cusabio |
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Description: Quantitativecompetitive ELISA kit for measuring Human Coenzyme Q10 (CoQ10) in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits. |
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Human Coenzyme Q10 (CoQ10)ELISA Kit |
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| YLA0138HU-48T | Shanghai YL Biotech | 48T | Ask for price |
Human Coenzyme Q10 (CoQ10)ELISA Kit |
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| YLA0138HU-96T | Shanghai YL Biotech | 96T | Ask for price |
Human Coenzyme Q10,CoQ10 ELISA KIT |
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| EA0076Hu | Jiaxing Korain Biotech Ltd (BT Labs) | 96 wells | EUR 458 |
Human CoQ10(Coenzyme Q10) ELISA Kit |
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| ELK9177-48T | ELK Biotech | 48T | Ask for price |
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Description: This assay employs the competitive inhibition enzyme immunoassay technique. The microtiter plate provided in this kit has been pre-coated with Human CoQ10 protein. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human CoQ10. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Human CoQ10 in the samples is then determined by comparing the OD of the samples to the standard curve. |
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Human CoQ10(Coenzyme Q10) ELISA Kit |
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| ELK9177-96T | ELK Biotech | 96T | Ask for price |
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Description: This assay employs the competitive inhibition enzyme immunoassay technique. The microtiter plate provided in this kit has been pre-coated with Human CoQ10 protein. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human CoQ10. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Human CoQ10 in the samples is then determined by comparing the OD of the samples to the standard curve. |
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Mouse CoQ10(Coenzyme Q10) ELISA Kit |
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| ELK9573-48T | ELK Biotech | 48T | Ask for price |
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Description: This assay employs the competitive inhibition enzyme immunoassay technique. The microtiter plate provided in this kit has been pre-coated with Mouse CoQ10 protein. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Mouse CoQ10. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Mouse CoQ10 in the samples is then determined by comparing the OD of the samples to the standard curve. |
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Mouse CoQ10(Coenzyme Q10) ELISA Kit |
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| ELK9573-96T | ELK Biotech | 96T | Ask for price |
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Description: This assay employs the competitive inhibition enzyme immunoassay technique. The microtiter plate provided in this kit has been pre-coated with Mouse CoQ10 protein. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Mouse CoQ10. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Mouse CoQ10 in the samples is then determined by comparing the OD of the samples to the standard curve. |
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Sheep Coenzyme Q10 (CoQ10) ELISA Kit |
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| SL00062Sp | Sunlong | - | Ask for price |
Horse Coenzyme Q10 (CoQ10) ELISA Kit |
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| SL0028Ho | Sunlong | - | EUR 528 |
Human Coenzyme Q10 (CoQ10) ELISA Kit |
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| SL2187Hu | Sunlong | 96 Tests | EUR 468 |
Human Coenzyme Q10 (CoQ10) ELISA Kit |
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| AE49401HU-48T | Abebio | 48T | EUR 360 |
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Description: Human (Homo sapiens) |
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Human Coenzyme Q10 (CoQ10) ELISA Kit |
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| AE49401HU-96T | Abebio | 96T | EUR 680 |
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Description: Human (Homo sapiens) |
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Human Coenzyme Q10, CoQ10 ELISA Kit |
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| MBS701260-10x96StripWells | MyBiosource | 10x96-Strip-Wells | EUR 5925 |
Human Coenzyme Q10, CoQ10 ELISA Kit |
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| MBS701260-24StripWellsLIMIT1 | MyBiosource | 24-Strip-Wells(LIMIT1) | EUR 275 |
Human Coenzyme Q10, CoQ10 ELISA Kit |
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| MBS701260-48StripWells | MyBiosource | 48-Strip-Wells | EUR 600 |
Human Coenzyme Q10, CoQ10 ELISA Kit |
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| MBS701260-5x96StripWells | MyBiosource | 5x96-Strip-Wells | EUR 3105 |
Human Coenzyme Q10, CoQ10 ELISA Kit |
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| MBS701260-96StripWells | MyBiosource | 96-Strip-Wells | EUR 855 |
Sheep Coenzyme Q10 (CoQ10) ELISA Kit |
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| MBS7252409-10x96StripWells | MyBiosource | 10x96-Strip-Wells | EUR 5685 |
Sheep Coenzyme Q10 (CoQ10) ELISA Kit |
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| MBS7252409-48StripWells | MyBiosource | 48-Strip-Wells | EUR 485 |
Sheep Coenzyme Q10 (CoQ10) ELISA Kit |
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| MBS7252409-5x96StripWells | MyBiosource | 5x96-Strip-Wells | EUR 3020 |
Sheep Coenzyme Q10 (CoQ10) ELISA Kit |
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| MBS7252409-96StripWells | MyBiosource | 96-Strip-Wells | EUR 690 |
Mouse Coenzyme Q10 (CoQ10) ELISA Kit |
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| MBS7233016-10x96StripWells | MyBiosource | 10x96-Strip-Wells | EUR 5685 |
Mouse Coenzyme Q10 (CoQ10) ELISA Kit |
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| MBS7233016-48StripWells | MyBiosource | 48-Strip-Wells | EUR 485 |
Mouse Coenzyme Q10 (CoQ10) ELISA Kit |
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| MBS7233016-5x96StripWells | MyBiosource | 5x96-Strip-Wells | EUR 3020 |
Mouse Coenzyme Q10 (CoQ10) ELISA Kit |
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| MBS7233016-96StripWells | MyBiosource | 96-Strip-Wells | EUR 690 |
Human Coenzyme Q10 (CoQ10) ELISA Kit |
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| MBS7225538-10x96StripWells | MyBiosource | 10x96-Strip-Wells | EUR 5685 |
Overall, the results show that our built-LBDs rat ERα interact with ligands in like manner with the human receptors, thus providing a high level of confidence in the extrapolation of rodent human receptor-ligand interactions.