Retrospective analysis of model-based predictivity of human pharmacokinetics for anti-IL-36R monoclonal antibody MAB92 using a rat anti-mouse IL-36R monoclonal antibody and RNA expression data (FANTOM5).
the accurate prediction of human pharmacokinetics (PK) of candidate monoclonal antibodies non-clinical data is essential to maximize the success of clinical trials. However, to monoclonal antibodies exhibiting nonlinear license for …